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Interaction of Cholesterol with Perfringolysin O: What Have We Learned from Functional Analysis?

Cholesterol-dependent cytolysins (CDCs) constitute a family of pore-forming toxins secreted by Gram-positive bacteria. These toxins form transmembrane pores by inserting a large β-barrel into cholesterol-containing membranes. Cholesterol is absolutely required for pore-formation. For most CDCs, bind...

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Bibliografische gegevens
Gepubliceerd in:Toxins (Basel)
Hoofdauteurs: Savinov, Sergey N., Heuck, Alejandro P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2017
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744101/
https://ncbi.nlm.nih.gov/pubmed/29168745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9120381
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