Prostaglandin E(2) Impairs P2Y(2)/P2Y(4) Receptor Signaling in Cerebellar Astrocytes via EP3 Receptors

Prostaglandin E(2) (PGE(2)) is an important bioactive lipid that accumulates after tissue damage or inflammation due to the rapid expression of cyclooxygenase 2. PGE(2) activates specific G-protein coupled EP receptors and it mediates pro- or anti-inflammatory actions depending on the cell-context....

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Udgivet i:Front Pharmacol
Main Authors: Paniagua-Herranz, Lucía, Gil-Redondo, Juan C., Queipo, Ma José, González-Ramos, Silvia, Boscá, Lisardo, Pérez-Sen, Raquel, Miras-Portugal, Ma Teresa, Delicado, Esmerilda G.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743739/
https://ncbi.nlm.nih.gov/pubmed/29311938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00937
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