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Elevated Cyclic AMP levels promote BRAF(CA)/Pten(−/−) mouse melanoma growth but pCREB is negatively correlated with human melanoma progression
Melanocyte development and differentiation are regulated by cAMP, which is produced by the adenylate cyclase (AC) enzyme upon activation of the melanocortin-1-receptor (MC1R). Individuals carrying single amino acid substitution variants of MC1R have impaired cAMP signaling and higher risk of melanom...
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| Publicat a: | Cancer Lett |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5743623/ https://ncbi.nlm.nih.gov/pubmed/29179997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.11.027 |
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