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Induction of Autophagy and Inhibition of Melanoma Growth In Vitro and In Vivo by Hyperactivation of Oncogenic BRAF

Activating mutations in NRAS and BRAF are found frequently in cutaneous melanomas. Because concurrent mutations of both BRAF and RAS are extremely rare, it is thought that transformation by RAS and BRAF occurs through a common mechanism. Also, there is evidence for a relationship of synthetic lethal...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Maddodi, Nityanand, Huang, Wei, Havighurst, Thomas, Kim, KyungMann, Longley, B. Jack, Setaluri, Vijayasaradhi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869390/
https://ncbi.nlm.nih.gov/pubmed/20182446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2010.26
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