Induction of Autophagy and Inhibition of Melanoma Growth In Vitro and In Vivo by Hyperactivation of Oncogenic BRAF

Activating mutations in NRAS and BRAF are found frequently in cutaneous melanomas. Because concurrent mutations of both BRAF and RAS are extremely rare, it is thought that transformation by RAS and BRAF occurs through a common mechanism. Also, there is evidence for a relationship of synthetic lethal...

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Bibliographische Detailangaben
Hauptverfasser: Maddodi, Nityanand, Huang, Wei, Havighurst, Thomas, Kim, KyungMann, Longley, B. Jack, Setaluri, Vijayasaradhi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869390/
https://ncbi.nlm.nih.gov/pubmed/20182446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2010.26
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