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In Vitro Bypass of Thymidine Glycol by DNA Polymerase Theta Forms Sequence-Dependent Frameshift Mutations
Unrepaired DNA lesions block replication and threaten genomic stability. Several specialized translesion polymerases, including Pol θ, contribute to replicative bypass of these lesions. The role of Pol θ in double strand break repair is well understood, but its contribution to translesion synthesis...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5743609/ https://ncbi.nlm.nih.gov/pubmed/29243925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01093 |
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