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Human leukocyte antigens: key regulators of T-cell mediated drug hypersensitivity

Adverse drug reactions (ADR) can be broadly categorised as either on-target or off-target. On-target ADRs arise as a direct consequence of the pharmacological properties of the drug and are therefore predictable and dose dependant. On-target ADRs comprise the majority (>80%) of ADRs, relate to th...

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Dettagli Bibliografici
Pubblicato in:HLA
Autori principali: Redwood, Alec J., Pavlos, Rebecca K., White, Katie D., Phillips, Elizabeth J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743596/
https://ncbi.nlm.nih.gov/pubmed/29171940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tan.13183
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