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Arachidonic Acid Metabolism by Human Cardiovascular CYP2J2 is Modulated by Doxorubicin
Doxorubicin (DOX) is a chemotherapeutic that is used in the treatment of a wide variety of cancers. However, it causes cardiotoxicity partly due to the formation of reactive oxygen species (ROS). CYP2J2 is a human cytochrome P450 that is highly expressed in cardiomyocytes. It converts arachidonic ac...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5743546/ https://ncbi.nlm.nih.gov/pubmed/29200270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01025 |
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