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Asymmetric binding and metabolism of polyunsaturated fatty acids (PUFAs) by CYP2J2 epoxygenase

Cytochrome P450 (CYP) 2J2 is the primary epoxygenase in the heart and is responsible for the epoxidation of arachidonic acid (AA), an ω-6 polyunsaturated fatty acid (PUFA), into anti-inflammatory epoxide metabolites. It also epoxidizes other PUFAs such as docosahexaenoic acid (DHA), linoleic acid (L...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Arnold, William R., Baylon, Javier L., Tajkhorshid, Emad, Das, Aditi
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558443/
https://ncbi.nlm.nih.gov/pubmed/27992998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01037
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