HIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase

The viral protein R (Vpr) is an accessory virulence factor of HIV-1 that facilitates infection in immune cells. Cellular functions of Vpr are tied to its interaction with DCAF1, a substrate receptor component of the CRL4 E3 ubiquitin ligase. Recent proteomic approaches suggested that Vpr degrades he...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Zhou, Xiaohong, DeLucia, Maria, Hao, Caili, Hrecka, Kasia, Monnie, Christina, Skowronski, Jacek, Ahn, Jinwoo
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743084/
https://ncbi.nlm.nih.gov/pubmed/29079575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.798801
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