TNF-stimulated gene 6 promotes formation of hyaluronan–inter-α-inhibitor heavy chain complexes necessary for ozone-induced airway hyperresponsiveness

Exposure to pollutants, such as ozone, exacerbates airway inflammation and hyperresponsiveness (AHR). TNF-stimulated gene 6 (TSG-6) is required to transfer inter-α-inhibitor heavy chains (HC) to hyaluronan (HA), facilitating HA receptor binding. TSG-6 is necessary for AHR in allergic asthma, because...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Stober, Vandy P., Johnson, Collin G., Majors, Alana, Lauer, Mark E., Cali, Valbona, Midura, Ronald J., Wisniewski, Hans-Georg, Aronica, Mark A., Garantziotis, Stavros
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743062/
https://ncbi.nlm.nih.gov/pubmed/29122888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756627
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