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Metformin protects against intestinal barrier dysfunction via AMPKα1‐dependent inhibition of JNK signalling activation
Disruption of the intestinal epithelial barrier, that involves the activation of C‐Jun N‐terminal kinase (JNK), contributes to initiate and accelerate inflammation in inflammatory bowel disease. Metformin has unexpected beneficial effects other than glucose‐lowering effects. Here, we provided eviden...
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| Udgivet i: | J Cell Mol Med |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5742676/ https://ncbi.nlm.nih.gov/pubmed/29148173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13342 |
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