Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque

OBJECTIVES: Anti-citrullinated peptides antibodies (ACPAs) have high specificity for the diagnosis of rheumatoid arthritis (RA), but their role in the pathophysiology is not fully established. The main genetic risk factor for RA, the shared epitope in major histocompatibility complex class II, is as...

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Publicat a:Front Immunol
Autors principals: Bitoun, Samuel, Roques, Pierre, Larcher, Thibaut, Nocturne, Gaétane, Serguera, Che, Chrétien, Pascale, Serre, Guy, Grand, Roger Le, Mariette, Xavier
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742322/
https://ncbi.nlm.nih.gov/pubmed/29326703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01816
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