Both Systemic and Intra-articular Immunization with Citrullinated Peptides Are Needed to Induce Arthritis in the Macaque

OBJECTIVES: Anti-citrullinated peptides antibodies (ACPAs) have high specificity for the diagnosis of rheumatoid arthritis (RA), but their role in the pathophysiology is not fully established. The main genetic risk factor for RA, the shared epitope in major histocompatibility complex class II, is as...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Bitoun, Samuel, Roques, Pierre, Larcher, Thibaut, Nocturne, Gaétane, Serguera, Che, Chrétien, Pascale, Serre, Guy, Grand, Roger Le, Mariette, Xavier
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742322/
https://ncbi.nlm.nih.gov/pubmed/29326703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01816
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