Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes

In silico cardiac myocyte models present powerful tools for drug safety testing and for predicting phenotypical consequences of ion channel mutations, but their accuracy is sometimes limited. For example, several models describing human ventricular electrophysiology perform poorly when simulating ef...

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Vydáno v:Front Physiol
Hlavní autoři: Krogh-Madsen, Trine, Jacobson, Anna F., Ortega, Francis A., Christini, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742183/
https://ncbi.nlm.nih.gov/pubmed/29311985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.01059
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