Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo

Aims: Chlorogenic acid (CGA) is a phenolic acid that has a wide range of pharmacological effects. However, the protective effects and mechanisms of CGA on liver fibrosis are not clear. This study explored the effects of CGA on miR-21-regulated TGF-β1/Smad7 liver fibrosis in the hepatic stellate LX2...

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Publicat a:Front Pharmacol
Autors principals: Yang, Fan, Luo, Lei, Zhu, Zhi-De, Zhou, Xuan, Wang, Yao, Xue, Juan, Zhang, Juan, Cai, Xin, Chen, Zhi-Lin, Ma, Qian, Chen, Yun-Fei, Wang, Yu-Jie, Luo, Ying-Ying, Liu, Pan, Zhao, Lei
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742161/
https://ncbi.nlm.nih.gov/pubmed/29311932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00929
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