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Identification of cryptolepine metabolites in rat and human hepatocytes and metabolism and pharmacokinetics of cryptolepine in Sprague Dawley rats

BACKGROUND: This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenous pharmacokinetics of cryptolepine in male Spragu...

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Detalhes bibliográficos
Publicado no:BMC Pharmacol Toxicol
Main Authors: Forkuo, Arnold Donkor, Ansah, Charles, Pearson, David, Gertsch, Werner, Cirello, Amanda, Amaral, Adam, Spear, Jaimie, Wright, Colin W., Rynn, Caroline
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741962/
https://ncbi.nlm.nih.gov/pubmed/29273084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-017-0188-8
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