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Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation

Bone marrow-derived mesenchymal stem cells (MSC) have been promoted for multiple therapeutic applications. Many beneficial effects of MSCs are paracrine, dependent on extracellular vesicles (EVs). Although MSC-derived EVs (mEVs) are beneficial for acute lung injury and pulmonary fibrosis, mechanisms...

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Pubblicato in:Sci Rep
Autori principali: Shentu, Tzu-Pin, Huang, Tse-Shun, Cernelc-Kohan, Mateja, Chan, Joy, Wong, Simon S., Espinoza, Celia R., Tan, Chunting, Gramaglia, Irene, van der Heyde, Henri, Chien, Shu, Hagood, James S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741716/
https://ncbi.nlm.nih.gov/pubmed/29273797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18288-9
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