A PERK-miR211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

The Unfolded Protein Response (UPR), is a stress activated signaling pathway that regulates cell proliferation, metabolism and survival. The circadian clock coordinates metabolism and signal transduction with light/dark cycles. We have explored how UPR signaling interfaces with the circadian clock....

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Detalhes bibliográficos
Publicado no:Nat Cell Biol
Main Authors: Bu, Yiwen, Yoshida, Akihiro, Chitnis, Nilesh, Altman, Brian J., Tameire, Feven, Oran, Amanda, Gennaro, Victoria, Armeson, Kent E., McMahon, Steven, Wertheim, Gerald B., Van Dang, Chi, Ruggero, Davide, Koumenis, Constantinos, Fuchs, Serge Y., Diehl, J. Alan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741512/
https://ncbi.nlm.nih.gov/pubmed/29230015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-017-0006-y
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