Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system

Type 1 iodothyronine deiodinase (DIO1) contributes to deiodination of 3,5,3’,5’-tetraiodo-L-thyronine (thyroxine, T4) yielding of 3,5,3’-triiodothyronine (T3), a powerful regulator of cell differentiation, proliferation, and metabolism. Our previous work showed that loss of DIO1 enhances proliferati...

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Publicado en:PLoS One
Autores principales: Popławski, Piotr, Wiśniewski, Jacek R., Rijntjes, Eddy, Richards, Keith, Rybicka, Beata, Köhrle, Josef, Piekiełko-Witkowska, Agnieszka
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741248/
https://ncbi.nlm.nih.gov/pubmed/29272308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190179
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