DNAJB1–PRKACA fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

A segmental deletion resulting in DNAJB1–PRKACA gene fusion is now recognized as the signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents and young adults. Here we implement CRISPR-Cas9 genome editing and transp...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kastenhuber, Edward R., Lalazar, Gadi, Houlihan, Shauna L., Tschaharganeh, Darjus F., Baslan, Timour, Chen, Chi-Chao, Requena, David, Tian, Sha, Bosbach, Benedikt, Wilkinson, John E., Simon, Sanford M., Lowe, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740683/
https://ncbi.nlm.nih.gov/pubmed/29162699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716483114
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