Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling

TGF-β/BMP (bone morphogenetic protein) signaling pathways play conserved roles in controlling embryonic development, tissue homeostasis, and stem cell regulation. Inhibitory Smads (I-Smads) have been shown to negatively regulate TGF-β/BMP signaling by primarily targeting the type I receptors for ubi...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Li, Wenqing, Li, Weini, Zou, Lihui, Ji, Shanming, Li, Chaoyi, Liu, Kehui, Zhang, Guoqiang, Sun, Qinmiao, Xiao, Fei, Chen, Dahua
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740658/
https://ncbi.nlm.nih.gov/pubmed/29180412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710540114
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