Loss of APOBEC1 RNA-editing function in microglia exacerbates age-related CNS pathophysiology

Microglia (MG), a heterogeneous population of phagocytic cells, play important roles in central nervous system (CNS) homeostasis and neural plasticity. Under steady-state conditions, MG maintain homeostasis by producing antiinflammatory cytokines and neurotrophic factors, support myelin production,...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cole, Daniel C., Chung, Youngcheul, Gagnidze, Khatuna, Hajdarovic, Kaitlyn H., Rayon-Estrada, Violeta, Harjanto, Dewi, Bigio, Benedetta, Gal-Toth, Judit, Milner, Teresa A., McEwen, Bruce S., Papavasiliou, F. Nina, Bulloch, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740644/
https://ncbi.nlm.nih.gov/pubmed/29167375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710493114
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