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Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is an X-linked disorder with dystrophin loss that results in skeletal and cardiac muscle weakening and early death. Loss of the dystrophin–sarcoglycan complex delocalizes nitric oxide synthase (NOS) to alter its signaling, and augments mechanosensitive intracellular...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Chung, Heaseung Sophia, Kim, Grace E., Holewinski, Ronald J., Venkatraman, Vidya, Zhu, Guangshuo, Bedja, Djahida, Kass, David A., Van Eyk, Jennifer E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740634/
https://ncbi.nlm.nih.gov/pubmed/29187535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712623114
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