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Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is an X-linked disorder with dystrophin loss that results in skeletal and cardiac muscle weakening and early death. Loss of the dystrophin–sarcoglycan complex delocalizes nitric oxide synthase (NOS) to alter its signaling, and augments mechanosensitive intracellular...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Chung, Heaseung Sophia, Kim, Grace E., Holewinski, Ronald J., Venkatraman, Vidya, Zhu, Guangshuo, Bedja, Djahida, Kass, David A., Van Eyk, Jennifer E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740634/
https://ncbi.nlm.nih.gov/pubmed/29187535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712623114
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