Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks

BACKGROUND: Breast cancer (BC) is the most common malignancy in women and has a major heritable component. The risks associated with most rare susceptibility variants are not well estimated. To better characterise the contribution of variants in ATM, CHEK2, PALB2 and XRCC2, we sequenced their coding...

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Detalhes bibliográficos
Publicado no:J Med Genet
Main Authors: Decker, Brennan, Allen, Jamie, Luccarini, Craig, Pooley, Karen A, Shah, Mitul, Bolla, Manjeet K, Wang, Qin, Ahmed, Shahana, Baynes, Caroline, Conroy, Don M, Brown, Judith, Luben, Robert, Ostrander, Elaine A, Pharoah, Paul DP, Dunning, Alison M, Easton, Douglas F
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Cancer Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740532/
https://ncbi.nlm.nih.gov/pubmed/28779002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2017-104588
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