Evaluation of Oritavancin Dosing Strategies against Vancomycin-Resistant Enterococcus faecium Isolates with or without Reduced Susceptibility to Daptomycin in an In Vitro Pharmacokinetic/Pharmacodynamic Model

The clinical development of nonsusceptibility to the lipopeptide antibiotic daptomycin remains a serious concern during therapy for infections caused by vancomycin-resistant Enterococcus faecium (VREfm). The long-acting lipoglycopeptide oritavancin exhibits potent in vitro activity against VREfm, al...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Belley, Adam, Arhin, Francis F., Moeck, Greg
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740372/
https://ncbi.nlm.nih.gov/pubmed/29109163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01873-17
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