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Assessing the Combined Antibacterial Effect of Isoniazid and Rifampin on Four Mycobacterium tuberculosis Strains Using In Vitro Experiments and Response-Surface Modeling

While isoniazid and rifampin have been the cornerstone of tuberculosis therapy caused by drug-susceptible Mycobacterium tuberculosis for more than 40 years, their combined action has never been thoroughly assessed by modern quantitative pharmacology approaches. The aims of this work were to perform...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Genestet, Charlotte, Ader, Florence, Pichat, Catherine, Lina, Gérard, Dumitrescu, Oana, Goutelle, Sylvain
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740320/
https://ncbi.nlm.nih.gov/pubmed/29061753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01413-17
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