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FL‐926‐16, a novel bioavailable carnosinase‐resistant carnosine derivative, prevents onset and stops progression of diabetic nephropathy in db/db mice
BACKGROUND AND PURPOSE: The advanced glycation end products (AGEs) participate in the pathogenesis of diabetic nephropathy (DN) by promoting renal inflammation and injury. L‐carnosine acts as a quencher of the AGE precursors reactive carbonyl species (RCS), but is rapidly inactivated by carnosinase....
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5740255/ https://ncbi.nlm.nih.gov/pubmed/29053168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14070 |
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