Deep sequencing of blood and gut T-cell receptor β-chains reveals gluten-induced immune signatures in celiac disease

Celiac disease (CD) patients mount an abnormal immune response to gluten. T-cell receptor (TCR) repertoires directed to some immunodominant gluten peptides have previously been described, but the global immune response to in vivo gluten exposure in CD has not been systematically investigated yet. He...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Yohannes, Dawit A., Freitag, Tobias L., de Kauwe, Andrea, Kaukinen, Katri, Kurppa, Kalle, Wacklin, Pirjo, Mäki, Markku, Arstila, T. Petteri, Anderson, Robert P., Greco, Dario, Saavalainen, Päivi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740085/
https://ncbi.nlm.nih.gov/pubmed/29269859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-18137-9
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