Genetic fine-mapping and identification of candidate genes and variants for adiposity traits in outbred rats

OBJECTIVE: Obesity is a major risk factor for multiple diseases and is in part heritable, yet the majority of causative genetic variants that drive excessive adiposity remain unknown. Here, we used outbred heterogeneous stock (HS) rats in controlled environmental conditions to fine-map novel genetic...

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Detalhes bibliográficos
Publicado no:Obesity (Silver Spring)
Main Authors: Keele, Gregory R., Prokop, Jeremy W., He, Hong, Holl, Katie, Littrell, John, Deal, Aaron, Francic, Sanja, Cui, Leilei, Gatti, Daniel M., Broman, Karl W., Tschannen, Michael, Tsaih, Shirng-Wern, Zagloul, Maie, Kim, Yunjung, Baur, Brittany, Fox, Joseph, Robinson, Melanie, Levy, Shawn, Flister, Michael J., Mott, Richard, Valdar, William, Solberg Woods, Leah C
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5740008/
https://ncbi.nlm.nih.gov/pubmed/29193816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.22075
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