Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics

Indoxacarb and metaflumizone are two sodium channel blocker insecticides (SCBIs). They preferably bind to and trap sodium channels in the slow-inactivated non-conducting state, a mode of action similar to that of local anesthetics (LAs). Recently, two sodium channel mutations, F1845Y (F(4i15)Y) and...

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Publicado en:Insect Biochem Mol Biol
Autores principales: Jiang, Dingxin, Du, Yuzhe, Nomura, Yoshiko, Wang, Xingliang, Wu, Yidong, Zhorov, Boris S., Dong, Ke
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739882/
https://ncbi.nlm.nih.gov/pubmed/26407935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ibmb.2015.09.011
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