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BTK blocks the inhibitory effects of MDM2 on p53 activity
p53 is a tumour suppressor that is activated in response to various types of stress. It is regulated by a complex pattern of over 50 different post-translational modifications, including ubiquitination by the E3 ligase MDM2, which leads to its proteasomal degradation. We have previously reported tha...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5739762/ https://ncbi.nlm.nih.gov/pubmed/29290977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22543 |
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