SPC24 promotes osteosarcoma progression by increasing EGFR/MAPK signaling

In this study, we investigated the role of the spindle checkpoint protein SPC24 in osteosarcoma progression. SPC24 knockdown in 143B and U2OS osteosarcoma cells decreased cell growth, survival and invasiveness. The SPC24 knockdown cells also exhibited low EGFR, Ras and phospho-ERK levels and high E-...

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Sparad:
Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Sheng, Jun, Yin, Mengchen, Sun, Zhengwang, Kang, Xia, Liu, Da, Jiang, Kai, Xu, Jia, Zhao, Feixing, Guo, Qunfeng, Zheng, Wei
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2017
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739637/
https://ncbi.nlm.nih.gov/pubmed/29285250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22167
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