SPC24 promotes osteosarcoma progression by increasing EGFR/MAPK signaling

In this study, we investigated the role of the spindle checkpoint protein SPC24 in osteosarcoma progression. SPC24 knockdown in 143B and U2OS osteosarcoma cells decreased cell growth, survival and invasiveness. The SPC24 knockdown cells also exhibited low EGFR, Ras and phospho-ERK levels and high E-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sheng, Jun, Yin, Mengchen, Sun, Zhengwang, Kang, Xia, Liu, Da, Jiang, Kai, Xu, Jia, Zhao, Feixing, Guo, Qunfeng, Zheng, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739637/
https://ncbi.nlm.nih.gov/pubmed/29285250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22167
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