Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer

The scaffold protein Spinophilin (Spinophilin, PPP1R9B) is one of the regulatory subunits of phosphatase-1 (PP1), directing it to distinct subcellular locations and targets. The loss of Spinophilin reduces PP1 targeting to pRb, thereby maintaining higher levels of phosphorylated pRb. Spinophilin is...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Verdugo-Sivianes, Eva M., Navas, Lola, Molina-Pinelo, Sonia, Ferrer, Irene, Quintanal-Villalonga, Alvaro, Peinado, Javier, Garcia-Heredia, Jose M., Felipe-Abrio, Blanca, Muñoz-Galvan, Sandra, Marin, Juan J., Montuenga, Luis, Paz-Ares, Luis, Carnero, Amancio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739631/
https://ncbi.nlm.nih.gov/pubmed/29285244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22111
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