Outcome of EGFR-mutated NSCLC patients with MET-driven resistance to EGFR tyrosine kinase inhibitors

BACKGROUND: Several mechanisms of acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) in EGFR-mutated NSCLC have been described including the T790M mutation and MET amplification. Whereas T790M mutation confers prolonged survival and sensitivity to 3rd generation TKIs, data are lacking on...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Baldacci, Simon, Mazieres, Julien, Tomasini, Pascale, Girard, Nicolas, Guisier, Florian, Audigier-Valette, Clarisse, Monnet, Isabelle, Wislez, Marie, Pérol, Maurice, Dô, Pascal, Dansin, Eric, Leduc, Charlotte, Giroux Leprieur, Etienne, Moro-Sibilot, Denis, Tulasne, David, Kherrouche, Zoulika, Labreuche, Julien, Cortot, Alexis B.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739624/
https://ncbi.nlm.nih.gov/pubmed/29285237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21707
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