Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy

Emerging evidence suggests that NLRP3 inflammasome provides a link between colitis-associated colorectal cancer and inflammatory bowel diseases. Autophagy is induced in macrophages by AMPK activation and regulates NLRP3 inflammasome to maintain intracellular homeostasis. Here we report that a small-...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Zhao, Yue, Guo, Qinglong, Zhao, Kai, Zhou, Yuxin, Li, Wenjun, Pan, Chuyue, Qiang, Lei, Li, Zhiyu, Lu, Na
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2017
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739552/
https://ncbi.nlm.nih.gov/pubmed/29296531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1375640
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