Continuous administration of the mTORC1 inhibitor everolimus induces tolerance and decreases autophagy in mice

BACKGROUND AND PURPOSE: Everolimus is an allosteric inhibitor of the mechanistic target of rapamycin complex 1 (mTORC1) widely known for its potent autophagy stimulating properties. Because everolimus shows poor solubility and stability in aqueous solutions, long‐term in vivo administration in precl...

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Publicat a:Br J Pharmacol
Autors principals: Kurdi, Ammar, De Doncker, Mireille, Leloup, Arthur, Neels, Hugo, Timmermans, Jean‐Pierre, Lemmens, Katrien, Apers, Sandra, De Meyer, Guido R Y, Martinet, Wim
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738667/
https://ncbi.nlm.nih.gov/pubmed/27638766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13626
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