Tumour-associated neutrophils and loss of epithelial PTEN can promote corticosteroid-insensitive MMP-9 expression in the chronically inflamed lung microenvironment

Matrix metalloproteinase-9 (MMP-9) is increased in a number of pathological lung conditions, where the proteinase contributes to deleterious remodelling of the airways. While both lung cancer and COPD are associated with increased MMP-9 expression, the cellular and molecular drivers of MMP-9 remain...

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Detalhes bibliográficos
Publicado no:Thorax
Main Authors: Vannitamby, Amanda, Seow, Huei Jiunn, Anderson, Gary, Vlahos, Ross, Thompson, Michelle, Steinfort, Daniel, Irving, Louis B, Bozinovski, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Research Letter
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738540/
https://ncbi.nlm.nih.gov/pubmed/28202627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thoraxjnl-2016-209389
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