Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release

Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the maternal storage and zygotic release of histones H2A/H2B. Npm contains a pentameric N-terminal core domain and an intrinsically disordered C-terminal tail domain. Though intrinsically disordered regions are common among...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Warren, Christopher, Matsui, Tsutomu, Karp, Jerome M., Onikubo, Takashi, Cahill, Sean, Brenowitz, Michael, Cowburn, David, Girvin, Mark, Shechter, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738438/
https://ncbi.nlm.nih.gov/pubmed/29263320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02308-3
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