Natural parasite exposure induces protective human anti-malarial antibodies

Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal models, but are difficult to induce in humans. Here we cloned and characterized rare affinity-matured human NANP-reactive memo...

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Publicado no:Immunity
Main Authors: Triller, Gianna, Scally, Stephen W., Costa, Giulia, Pissarev, Maria, Kreschel, Cornelia, Bosch, Alexandre, Marois, Eric, Sack, Brandon K., Murugan, Rajagopal, Salman, Ahmed M., Janse, Chris J., Khan, Shahid M., Kappe, Stefan H., Adegnika, Ayola A., Mordmüller, Benjamin, Levashina, Elena A., Julien, Jean-Philippe, Wardemann, Hedda
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738265/
https://ncbi.nlm.nih.gov/pubmed/29195810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.11.007
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