BRD4 inhibitors block telomere elongation

Cancer cells maintain telomere length equilibrium to avoid senescence and apoptosis induced by short telomeres, which trigger the DNA damage response. Limiting the potential for telomere maintenance in cancer cells has been long been proposed as a therapeutic target. Using an unbiased shRNA screen t...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Wang, Steven, Pike, Alexandra M., Lee, Stella S., Strong, Margaret A., Connelly, Carla J., Greider, Carol W.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737673/
https://ncbi.nlm.nih.gov/pubmed/28854735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx561
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars