Telomere shortening triggers a feedback loop to enhance end protection

Telomere homeostasis is controlled by both telomerase machinery and end protection. Telomere shortening induces DNA damage sensing kinases ATM/ATR for telomerase recruitment. Yet, whether telomere shortening also governs end protection is poorly understood. Here we discover that yeast ATM/ATR contro...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Yang, Chia-Wei, Tseng, Shun-Fu, Yu, Chia-Jung, Chung, Chia-Yu, Chang, Cheng-Yen, Pobiega, Sabrina, Teng, Shu-Chun
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737367/
https://ncbi.nlm.nih.gov/pubmed/28575419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx503
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