The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer

We observed overexpression and increased intra-nuclear accumulation of the PRMT5/WDR77 in breast cancer cell lines relative to immortalized breast epithelial cells. Utilizing mass spectrometry and biochemistry approaches we identified the Zn-finger protein ZNF326, as a novel interaction partner and...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Rengasamy, Madhumitha, Zhang, Fan, Vashisht, Ajay, Song, Won-Min, Aguilo, Francesca, Sun, Yifei, Li, SiDe, Zhang, Weijia, Zhang, Bin, Wohlschlegel, James A., Walsh, Martin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737218/
https://ncbi.nlm.nih.gov/pubmed/28977470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx727
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