Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal cells. Through an unbiased CETSA screen, we identify the PIP4K lipid kinases as the target...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Kitagawa, Mayumi, Liao, Pei-Ju, Lee, Kyung Hee, Wong, Jasmine, Shang, See Cheng, Minami, Noriaki, Sampetrean, Oltea, Saya, Hideyuki, Lingyun, Dai, Prabhu, Nayana, Diam, Go Ka, Sobota, Radoslaw, Larsson, Andreas, Nordlund, Pär, McCormick, Frank, Ghosh, Sujoy, Epstein, David M., Dymock, Brian W., Lee, Sang Hyun
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736559/
https://ncbi.nlm.nih.gov/pubmed/29259156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02287-5
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы