End-Stage Renal Disease Causes Skewing in the TCR Vβ-Repertoire Primarily within CD8(+) T Cell Subsets

A broad T cell receptor (TCR-) repertoire is required for an effective immune response. TCR-repertoire diversity declines with age. End-stage renal disease (ESRD) patients have a prematurely aged T cell system which is associated with defective T cell-mediated immunity. Recently, we showed that ESRD...

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Publicado en:Front Immunol
Autores principales: Huang, Ling, Betjes, Michiel G. H., Klepper, Mariska, Langerak, Anton W., Baan, Carla C., Litjens, Nicolle H. R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736542/
https://ncbi.nlm.nih.gov/pubmed/29326709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01826
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