pERK-dependent defective TCR-mediated activation of CD4(+) T cells in end-stage renal disease patients

BACKGROUND: Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (ERK) and p38, regulate diverse cellular programs by transferring extracellular s...

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Detalhes bibliográficos
Publicado no:Immun Ageing
Main Authors: Huang, Ling, Litjens, Nicolle H. R., Kannegieter, Nynke M., Klepper, Mariska, Baan, Carla C., Betjes, Michiel G. H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477144/
https://ncbi.nlm.nih.gov/pubmed/28642802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12979-017-0096-1
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