Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: Relevance to gene and environment interactions in metal neurotoxicity

Parkinson's disease (PD) is now recognized as a neurodegenerative condition caused by a complex interplay of genetic and environmental influences. Chronic manganese (Mn) exposure has been implicated in the development of PD. Since mitochondrial dysfunction is associated with PD pathology as wel...

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Bibliografske podrobnosti
izdano v:Neurotoxicology
Main Authors: Langley, Monica R., Ghaisas, Shivani, Ay, Muhammet, Luo, Jie, Palanisamy, Bharathi N., Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Arthi, Kanthasamy, Anumantha G.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736468/
https://ncbi.nlm.nih.gov/pubmed/28595911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2017.06.002
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