The loss of TET2 promotes CD8(+) T cell memory differentiation

T cell differentiation requires appropriate regulation of DNA methylation. Here we demonstrate that the methylcytosine dioxygenase ten-eleven translocation 2 (TET2) regulates CD8(+) T cell differentiation. In a murine model of acute viral infection, TET2 loss promotes early acquisition of a memory C...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Carty, Shannon A., Gohil, Mercy, Banks, Lauren B., Cotton, Renee M, Johnson, Matthew E., Stelekati, Erietta, Wells, Andrew D., Wherry, E. John, Koretzky, Gary A., Jordan, Martha S.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736442/
https://ncbi.nlm.nih.gov/pubmed/29150566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700559
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