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MPK1/SLT2 links multiple stress responses with gene expression in budding yeast by phosphorylating Tyr1 of the RNAP II CTD

The RNA polymerase II largest subunit C-terminal domain consists of repeated YSPTSPS heptapeptides. The role of tyrosine-1 (Tyr1) remains incompletely understood, as, for example, mutating all Tyr1 residues to Phe (Y1F) is lethal in vertebrates but a related mutant has only a mild phenotype in S. po...

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Vydáno v:Mol Cell
Hlavní autoři: Yurko, Nathan, Liu, Xiaochuan, Yamazaki, Takashi, Hoque, Mainul, Tian, Bin, Manley, James L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736309/
https://ncbi.nlm.nih.gov/pubmed/29220656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.11.020
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