Disruption of the c-Myc/miR-200b-3p/PRDX2 regulatory loop enhances tumor metastasis and chemotherapeutic resistance in colorectal cancer

BACKGROUND: Metastasis is a major threat to colorectal cancer (CRC) patients. We have reported that peroxiredoxin-2 (PRDX2) is associated with CRC invasion and metastasis. However, the mechanisms regulating PRDX2 expression remain unclear. We investigate whether microRNAs (miRNAs) regulate PRDX2 exp...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Lv, Zhenbing, Wei, Jinlai, You, Wenxian, Wang, Rong, Shang, Jingkun, Xiong, Yongfu, Yang, Hua, Yang, Xuanhua, Fu, Zhongxue
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735915/
https://ncbi.nlm.nih.gov/pubmed/29258530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1357-7
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